1-(5-phospho-β-D-ribosyl)-ATP + diphosphate ↔ 5-phospho-α-D-ribose 1-diphosphate + ATP (R568)
- Overexpression
  - Genome
- Feedback insensitive
  - Genome
  - Plasmid
    - Escherichia coli BHS3
histidinol + NAD⁺ ↔ histidinal + NADH + H⁺ (R229)
- Overexpression
  - Genome
NAD⁺ + H₂O + histidinol → NADH + H⁺ + L-histidine (R613)
- Overexpression
  - Genome
H₂O + histidinal + NAD⁺ → H⁺ + NADH + L-histidine (R204)
- Overexpression
  - Genome
imidazole acetol-phosphate + L-glutamate ↔ L-histidinol phosphate + 2-oxoglutarate (R739)
- Overexpression
  - Genome
H₂O + L-histidinol phosphate → histidinol + phosphate (R521)
- Overexpression
  - Genome
D-erythro-imidazole-glycerol-phosphate → H₂O + imidazole acetol-phosphate (R210)
- Overexpression
  - Genome
L-glutamine + phosphoribulosylformimino-AICAR-phosphate → D-erythro-imidazole-glycerol-phosphate + H⁺ + L-glutamate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (R225)
- Overexpression
  - Genome
1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide → phosphoribulosylformimino-AICAR-phosphate (R501)
- Overexpression
  - Genome
H₂O + 1-(5-phospho-β-D-ribosyl)-AMP → 1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide (R687)
- Overexpression
  - Genome
H₂O + 1-(5-phospho-β-D-ribosyl)-ATP → H⁺ + 1-(5-phospho-β-D-ribosyl)-AMP + diphosphate (R231)
- Overexpression
  - Genome
acetate + ATP ↔ acetyl phosphate + ADP (R45)
- Silencing
  - Genome
aldehydo-D-ribose 5-phosphate + ATP ↔ 5-phospho-α-D-ribose 1-diphosphate + H⁺ + AMP (R115)
- Overexpression
  - Genome
D-gluconate 6-phosphate + NADP⁺ → D-ribulose 5-phosphate + NADPH + CO₂ (R202)
- Overexpression
  - Genome
β-D-glucose 6-phosphate + NADP⁺ → 6-phospho D-glucono-1,5-lactone + NADPH + H⁺ (R392)
- Overexpression
  - Genome
H₂O + ATP → H⁺ + diphosphate + AMP (R152)
- Silencing
  - Genome
H₂O + IMP → inosine + phosphate (R580)
- Silencing
  - Genome
H₂O + AMP → aldehydo-D-ribose 5-phosphate + adenine (R3061)
- Silencing
  - Genome
H₂O + IMP ↔ 5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide (R207)
- Overexpression
  - Genome
10-formyl-tetrahydrofolate mono-L-glutamate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ↔ 5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide (R119)
- Overexpression
  - Genome
L-aspartate + IMP + GTP → H⁺ + adenylo-succinate + phosphate + GDP (R244)
- Overexpression
  - Genome
adenylo-succinate ↔ fumarate + AMP (R337)
- Overexpression
  - Genome
5-phospho-β-D-ribosylamine + L-glutamate + diphosphate ↔ 5-phospho-α-D-ribose 1-diphosphate + H₂O + L-glutamine (R11)
- Silencing
  - Genome
H₂O + NAD⁺ + L-glutamate ↔ NADH + 2-oxoglutarate + H⁺ + ammonium (R1141)
- Overexpression
  - Genome
    - Escherichia coli HW5-1
    - Escherichia coli HW6-3
L-histidine → L-histidine (R00844)
- Overexpression
  - Genome
    - Escherichia coli HW6-3
D-erythrose 4-phosphate + D-xylulose 5-phosphate ↔ β-D-fructofuranose 6-phosphate + D-glyceraldehyde 3-phosphate (R372)
- Overexpression
  - Genome
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate ↔ aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate (R584)
- Overexpression
  - Genome
ATP + dTDP → ADP + dTTP (R731)
- Overexpression
  - Genome
dGDP + ATP → dGTP + ADP (R570)
- Overexpression
  - Genome
ATP + UDP → ADP + UTP (R373)
- Overexpression
  - Genome
dADP + ATP → ADP + dATP (R438)
- Overexpression
  - Genome
ATP + CDP ↔ ADP + CTP (R652)
- Overexpression
  - Genome
ATP + dCDP → ADP + dCTP (R145)
- Overexpression
  - Genome
GDP + ATP → GTP + ADP (R18)
- Overexpression
  - Genome
ATP + dUDP → ADP + dUTP (R679)
- Overexpression
  - Genome
H₂O + NADP⁺ + L-glutamate ↔ NADPH + 2-oxoglutarate + H⁺ + ammonium (R1179)
- Overexpression
  - Genome
ammonium + L-glutamate + ATP → H⁺ + L-glutamine + phosphate + ADP (R1195)
- Overexpression
  - Genome
NADH + ubiquinone-8 + H⁺ → ubiquinol-8 + NAD⁺ + H⁺ (R6528)
- Overexpression
  - Genome
    - Escherichia coli HIS5-11
menaquinol-8 + NAD⁺ + H⁺ ↔ menaquinone-8 + NADH + H⁺ (R00893)
- Overexpression
  - Genome
    - Escherichia coli HIS5-11