H₂O + NAD⁺ + hypoxanthine → xanthine + NADH + H⁺ (R979)
- Silencing
  - Genome
5-phospho-β-D-ribosylamine + L-glutamate + diphosphate ↔ 5-phospho-α-D-ribose 1-diphosphate + H₂O + L-glutamine (R11)
- Feedback insensitive
  - Genome
- Overexpression
  - Genome
aldehydo-D-ribose 5-phosphate + ATP ↔ 5-phospho-α-D-ribose 1-diphosphate + H⁺ + AMP (R115)
- Feedback insensitive
  - Genome
5-phospho-β-D-ribosylamine + glycine + ATP → N¹-(5-phospho-β-D-ribosyl)glycinamide + H⁺ + phosphate + ADP (R529)
- Overexpression
  - Genome
N¹-(5-phospho-β-D-ribosyl)glycinamide + 10-formyl-tetrahydrofolate mono-L-glutamate ↔ N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide + H⁺ + 5,6,7,8-tetrahydrofolate (R767)
- Overexpression
  - Genome
N¹-(5-phospho-β-D-ribosyl)glycinamide + formate + ATP → N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide + H⁺ + phosphate + ADP (R835)
- Overexpression
  - Genome
H₂O + N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide + L-glutamine + ATP → 2-(formamido)-N¹-(5-phospho-β-D-ribosyl)acetamidine + H⁺ + L-glutamate + phosphate + ADP (R561)
- Overexpression
  - Genome
2-(formamido)-N¹-(5-phospho-β-D-ribosyl)acetamidine + ATP → 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + H⁺ + phosphate + ADP (R31)
- Overexpression
  - Genome
H⁺ + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO₂ (R173)
- Overexpression
  - Genome
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP → 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + H⁺ + phosphate + ADP (R327)
- Overexpression
  - Genome
5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole ↔ fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (R242)
- Overexpression
  - Genome
L-aspartate + IMP + GTP → H⁺ + adenylo-succinate + phosphate + GDP (R244)
- Silencing
  - Genome
    - Escherichia coli Y1-2
    - Escherichia coli HX1-1
- Attenuation
  - Genome
    - Escherichia coli Y1-2
H₂O + adenosine + H⁺ → inosine + ammonium (R1082)
- Overexpression
  - Genome
H₂O + H⁺ + adenine → ammonium + hypoxanthine (R1911)
- Overexpression
  - Genome
H₂O + IMP → inosine + phosphate (R580)
- Overexpression
  - Genome
diphosphate + IMP ← 5-phospho-α-D-ribose 1-diphosphate + hypoxanthine (R542)
- Silencing
  - Genome
H₂O + NAD⁺ + IMP ↔ NADH + H⁺ + XMP (R221)
- Silencing
  - Genome
- Attenuation
  - Genome
adenylo-succinate ↔ fumarate + AMP (R337)
- Overexpression
  - Genome
ammonium + L-glutamate + ATP → H⁺ + L-glutamine + phosphate + ADP (R1195)
- Feedback insensitive
  - Genome
2-oxoglutarate + L-aspartate ↔ L-glutamate + oxaloacetate (R734)
- Overexpression
  - Genome
L-aspartate + ATP → L-aspartyl-4-phosphate + ADP (R295)
- Attenuation
  - Genome
L-homoserine + NAD(P)+ ← L-aspartate 4-semialdehyde + NAD(P)H + H⁺ (R234)
- Attenuation
  - Genome