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acetyl-CoA ↔ coenzyme A + acetoacetyl-CoA (R12)
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H2O + acetoacetyl-CoA + acetyl-CoA ↔ coenzyme A + H+ + (S)-3-hydroxy-3-methylglutaryl-CoA (R685)
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NADP+ + coenzyme A + (R)-mevalonate ↔ NADPH + H+ + (S)-3-hydroxy-3-methylglutaryl-CoA (R668)
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(R)-mevalonate + ATP ↔ (R)-5-phosphomevalonate + H+ + ADP (R630)
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(R)-5-phosphomevalonate + ATP ↔ (R)-mevalonate diphosphate + ADP (R716)
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(R)-mevalonate diphosphate + ATP → isopentenyl diphosphate + phosphate + ADP + CO2 (R465)
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isopentenyl diphosphate ↔ prenyl diphosphate (R123)
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isopentenyl diphosphate + prenyl diphosphate ↔ diphosphate + geranyl diphosphate (R315)
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isopentenyl diphosphate + geranyl diphosphate ↔ diphosphate + (2E,6E)-farnesyl diphosphate (R574)
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H2O + (2E,6E)-farnesyl diphosphate → diphosphate + (-)-patchoulol (R9930)
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acetate + ATP ↔ acetyl phosphate + ADP (R45)
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acetyl-CoA + phosphate ↔ coenzyme A + acetyl phosphate (R424)
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NAD+ + (R)-lactate ← NADH + pyruvate + H+ (R504)
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H+ + menaquinol-8 + fumarate → menaquinone-8 + succinate (R6531)