(<i>R</i>)-pantothenate charts

Silencing

Overexpression

Feedback insensitive

Attenuation

Feed-forward insensitive

Inhibition insensitive

Unstated

Combined modifications

Titer in Fed-Batch for (R)-pantothenate

		Modifications
Strain	Maximum production	panB_Ec	panC_Ec	glk_Ec	avtA_Ec	ilvE_Ec	ldhA_Ec	poxB_Ec	gltA_Ec	panE_Ec	gapC_Ca	sthA_Ec	ppnK_Cg	tolR_Ec
E. coli PA117	58,760 mg/L
E. coli PA132	83,260 mg/L

Titer in Flask for (R)-pantothenate

		Modifications
Strain	Maximum production	panB_Ec	panC_Ec	glk_Ec	avtA_Ec	ilvE_Ec	ldhA_Ec	pta_Ec	poxB_Ec	gltA_Ec	panE_Ec	gapC_Ca	ppnK_Cg	sthA_Ec	panB_Cg	panC_Cg	panC_Bs	panB_Bs	ilvB_Cg	gapA_Ec	panF_Ec	tolR_Ec
E. coli PA126	35 mg/L
E. coli PA106	260 mg/L
E. coli PA101	285 mg/L
E. coli PA102	314 mg/L
E. coli PA104	330 mg/L
E. coli PA105	360 mg/L
E. coli PA103	461 mg/L
E. coli PA128	499 mg/L
E. coli PA127	506 mg/L
E. coli PA107pA	564 mg/L
E. coli PA129	598 mg/L
E. coli PA107	810 mg/L
E. coli PA107pF	890 mg/L
E. coli PA109	940 mg/L
E. coli PA107pR	978 mg/L
E. coli PA130	1,090 mg/L
E. coli PA111	1,210 mg/L
E. coli PA107pC	1,450 mg/L
E. coli PA111 pBs	2,722 mg/L
E. coli PA111 pCg	2,766 mg/L
E. coli PA120	3,379 mg/L
E. coli PA115	3,530 mg/L
E. coli PA111 pEc	3,710 mg/L
E. coli PA112	3,727 mg/L
E. coli PA124	3,740 mg/L
E. coli PA114	3,750 mg/L
E. coli PA118	3,845 mg/L
E. coli PA113	3,870 mg/L
E. coli PA116	3,890 mg/L
E. coli PA122	3,990 mg/L
E. coli PA121	4,020 mg/L
E. coli PA117	4,270 mg/L
E. coli PA119	4,330 mg/L
E. coli PA131	4,566 mg/L
E. coli PA123	4,820 mg/L
E. coli PA125	4,930 mg/L
E. coli PA132	5,040 mg/L

Volumetric productivity in Flask for (R)-pantothenate

		Modifications
Strain	Maximum production	panB_Ec	panC_Ec	glk_Ec	avtA_Ec	ilvE_Ec	ldhA_Ec	poxB_Ec	gltA_Ec
E. coli PA112	50 mg/L/h
E. coli PA111 pEc	80 mg/L/h

Volumetric productivity in Fed-Batch for (R)-pantothenate

		Modifications
Strain	Maximum production	panB_Ec	panC_Ec	glk_Ec	avtA_Ec	ilvE_Ec	ldhA_Ec	poxB_Ec	gltA_Ec	panE_Ec	gapC_Ca	sthA_Ec	ppnK_Cg	tolR_Ec
E. coli PA132	1,740 mg/L/h

Substrate yield in Fed-Batch for (R)-pantothenate

		Modifications
Strain	Maximum production	panB_Ec	panC_Ec	glk_Ec	avtA_Ec	ilvE_Ec	ldhA_Ec	poxB_Ec	gltA_Ec	panE_Ec	gapC_Ca	sthA_Ec	ppnK_Cg	tolR_Ec
E. coli PA132	0.39 g/g of sustrate

Biomass-specific titer in Flask for (R)-pantothenate

		Modifications
Strain	Maximum production	panB_Ec	panC_Ec	glk_Ec	avtA_Ec	ilvE_Ec	ldhA_Ec	pta_Ec	poxB_Ec	gltA_Ec	panB_Cg	panC_Cg	panC_Bs	panB_Bs	panE_Ec	ilvB_Cg	gapC_Ca	gapA_Ec	tolR_Ec
E. coli PA101	-999,999,999
E. coli PA102	-999,999,999
E. coli PA103	-999,999,999
E. coli PA104	-999,999,999
E. coli PA105	-999,999,999
E. coli PA106	-999,999,999
E. coli PA107	-999,999,999
E. coli PA108	-999,999,999
E. coli PA109	-999,999,999
E. coli PA110	-999,999,999
E. coli PA111 pEc	-999,999,999
E. coli PA111 pCg	-999,999,999
E. coli PA111 pBs	-999,999,999
E. coli PA117	-999,999,999
E. coli PA116	-999,999,999
E. coli PA115	-999,999,999
E. coli PA114	-999,999,999
E. coli PA113	-999,999,999
E. coli PA118	-999,999,999
E. coli PA119	-999,999,999
E. coli PA120	-999,999,999
E. coli PA121	-999,999,999
E. coli PA122	-999,999,999
E. coli PA107pA	-999,999,999
E. coli PA107pC	-999,999,999
E. coli PA107pF	-999,999,999
E. coli PA107pR	-999,999,999
E. coli PA127	-999,999,999
E. coli PA128	-999,999,999
E. coli PA129	-999,999,999
E. coli PA130	-999,999,999