Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-dopa

Modifications
Strain Maximum production hpaBEc hpaCEc tyrREc csrAEc ptsIEc ptsHEc crrEc galPEc glkEc zwfEc pheAEc tyrAEc tyrBEc aroGEc tktAEc tyrCZm lacZEc
E. coli BW25113 (pQE-hpaBC) 138.7 mg/L
E. coli AROM-1 (pQE-hpaBC) 148.3 mg/L
E. coli AROM-3 (pQE-hpaBC) 173.9 mg/L
E. coli AROM-2 (pQE-hpaBC) 176 mg/L
E. coli AROM-4 (pQE-hpaBC) 205.3 mg/L
E. coli TYR-1 (pQE-hpaBC) 209.2 mg/L
E. coli DOPA-30 (pQE30) 210.2 mg/L
E. coli W3110ΔtyrR_DOPA 269 mg/L
E. coli DOPA-1 307.4 mg/L
E. coli VH33ΔtyrR_DOPA 320 mg/L
E. coli DOPA-30 (pQE30-2hpaBC) 490.3 mg/L
E. coli DOPA-30N 614.3 mg/L
E. coli DOPA-30 (pQE30-phaBCN) 650.3 mg/L

Titer in Fed-Batch for L-dopa

Modifications
Strain Maximum production tyrREc csrAEc ptsIEc ptsHEc crrEc galPEc glkEc zwfEc pheAEc tyrAEc tyrBEc hpaBEc hpaCEc
E. coli DOPA-30N 8,670 mg/L

Titer in Batch for L-dopa

Modifications
Strain Maximum production ptsIEc ptsHEc crrEc lacZEc galPEc tyrREc aroGEc tktAEc hpaBEc hpaCEc tyrCZm pheAEc
E. coli VH33ΔtyrR_DOPA 1,510 mg/L

Volumetric productivity in Fed-Batch for L-dopa

Modifications
Strain Maximum production tyrREc csrAEc ptsIEc ptsHEc crrEc galPEc glkEc zwfEc pheAEc tyrAEc tyrBEc hpaBEc hpaCEc
E. coli DOPA-30N 144.5 mg/L/h

Substrate yield in Fed-Batch for L-dopa

Modifications
Strain Maximum production tyrREc csrAEc ptsIEc ptsHEc crrEc galPEc glkEc zwfEc pheAEc tyrAEc tyrBEc hpaBEc hpaCEc
E. coli DOPA-30N 0.0627 g/g of sustrate

Substrate yield in Flask for L-dopa

Modifications
Strain Maximum production tyrREc aroGEc tktAEc hpaBEc hpaCEc tyrCZm pheAEc ptsIEc ptsHEc crrEc lacZEc galPEc
E. coli W3110ΔtyrR_DOPA 0.041 g/g of sustrate
E. coli VH33ΔtyrR_DOPA 0.054 g/g of sustrate