Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications
Titer in Flask for L-dopa
| Modifications | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | hpaBEc | hpaCEc | tyrREc | csrAEc | ptsIEc | ptsHEc | crrEc | galPEc | glkEc | zwfEc | pheAEc | tyrAEc | tyrBEc | aroGEc | tktAEc | tyrCZm | lacZEc |
| E. coli BW25113 (pQE-hpaBC) | 138.7 mg/L | |||||||||||||||||
| E. coli AROM-1 (pQE-hpaBC) | 148.3 mg/L | |||||||||||||||||
| E. coli AROM-3 (pQE-hpaBC) | 173.9 mg/L | |||||||||||||||||
| E. coli AROM-2 (pQE-hpaBC) | 176 mg/L | |||||||||||||||||
| E. coli AROM-4 (pQE-hpaBC) | 205.3 mg/L | |||||||||||||||||
| E. coli TYR-1 (pQE-hpaBC) | 209.2 mg/L | |||||||||||||||||
| E. coli DOPA-30 (pQE30) | 210.2 mg/L | |||||||||||||||||
| E. coli W3110ΔtyrR_DOPA | 269 mg/L | |||||||||||||||||
| E. coli DOPA-1 | 307.4 mg/L | |||||||||||||||||
| E. coli VH33ΔtyrR_DOPA | 320 mg/L | |||||||||||||||||
| E. coli DOPA-30 (pQE30-2hpaBC) | 490.3 mg/L | |||||||||||||||||
| E. coli DOPA-30N | 614.3 mg/L | |||||||||||||||||
| E. coli DOPA-30 (pQE30-phaBCN) | 650.3 mg/L | |||||||||||||||||
Titer in Fed-Batch for L-dopa
| Modifications | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrREc | csrAEc | ptsIEc | ptsHEc | crrEc | galPEc | glkEc | zwfEc | pheAEc | tyrAEc | tyrBEc | hpaBEc | hpaCEc |
| E. coli DOPA-30N | 8,670 mg/L | |||||||||||||
Titer in Batch for L-dopa
| Modifications | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | ptsIEc | ptsHEc | crrEc | lacZEc | galPEc | tyrREc | aroGEc | tktAEc | hpaBEc | hpaCEc | tyrCZm | pheAEc |
| E. coli VH33ΔtyrR_DOPA | 1,510 mg/L | ||||||||||||
Volumetric productivity in Fed-Batch for L-dopa
| Modifications | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrREc | csrAEc | ptsIEc | ptsHEc | crrEc | galPEc | glkEc | zwfEc | pheAEc | tyrAEc | tyrBEc | hpaBEc | hpaCEc |
| E. coli DOPA-30N | 144.5 mg/L/h | |||||||||||||
Substrate yield in Fed-Batch for L-dopa
| Modifications | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrREc | csrAEc | ptsIEc | ptsHEc | crrEc | galPEc | glkEc | zwfEc | pheAEc | tyrAEc | tyrBEc | hpaBEc | hpaCEc |
| E. coli DOPA-30N | 0.0627 g/g of sustrate | |||||||||||||
Substrate yield in Flask for L-dopa
| Modifications | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Strain | Maximum production | tyrREc | aroGEc | tktAEc | hpaBEc | hpaCEc | tyrCZm | pheAEc | ptsIEc | ptsHEc | crrEc | lacZEc | galPEc |
| E. coli W3110ΔtyrR_DOPA | 0.041 g/g of sustrate | ||||||||||||
| E. coli VH33ΔtyrR_DOPA | 0.054 g/g of sustrate | ||||||||||||