Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-isoleucine

Modifications
Strain Maximum production thrAEc lysCEc thrBEc thrCEc lysAEc metAEc ilvAEc tdhEc iclREc ppcEc ilvIEc ilvHEc ygaZEc ygaHEc ilvEEc ilvDEc ilvCEc lrpEc
E. coli ILE01 (pTacilvAIH, pBRthrABC) 322 mg/L
E. coli ILE01 (pTacilvAIH, pBRthrABCygaZH) 1,110 mg/L
E. coli ILE02 (pTacilvAIH, pBRthrABCygaZH) 2,110 mg/L
E. coli ILE03 (pTacilvAIH, pBRthrABCygaZH) 2,830 mg/L

Titer in Fed-Batch for L-isoleucine

Modifications
Strain Maximum production thrAEc lysCEc thrBEc thrCEc lysAEc metAEc ilvAEc tdhEc iclREc ppcEc ilvEEc ilvDEc ilvCEc lrpEc ilvIEc ilvHEc ygaZEc ygaHEc
E. coli ILE03 (pTacilvAIH, pBRthrABCygaZH) 9,460 mg/L

Volumetric productivity in Fed-Batch for L-isoleucine

Modifications
Strain Maximum production thrAEc lysCEc thrBEc thrCEc lysAEc metAEc ilvAEc tdhEc iclREc ppcEc ilvEEc ilvDEc ilvCEc lrpEc ilvIEc ilvHEc ygaZEc ygaHEc
E. coli ILE03 (pTacilvAIH, pBRthrABCygaZH) 158 mg/L/h

Substrate yield in Fed-Batch for L-isoleucine

Modifications
Strain Maximum production thrAEc lysCEc thrBEc thrCEc lysAEc metAEc ilvAEc tdhEc iclREc ppcEc ilvEEc ilvDEc ilvCEc lrpEc ilvIEc ilvHEc ygaZEc ygaHEc
E. coli ILE03 (pTacilvAIH, pBRthrABCygaZH) 0.14 g/g of sustrate